No Significant Risk Level (nsrls) for the Proposition 65 Carcinogens 3,3'-dimethylbenzidine and 3,3'-dimethylbenzidine Dihydrochloride
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چکیده
The cancer potencies of 3,3'-dimethylbenzidine (commonly called o-tolidine) and 3,3'dimethylbenzidine dihydrochloride were estimated from dose-response data for multiple treatment-responding tumor sites among male rats exposed orally to 3,3'-dimethylbenzidine dihydrochloride via drinking water (NTP, 1991). These sites included liver, lung, preputial gland, oral cavity, skin, small intestines, large intestines, and Zymbal’s gland. NTP (1991) noted other sites that may have been associated with treatment, but they were judged likely to contribute only minimally to the overall potency estimate and thus were not included in the analyses. For each of the tumor sites contributing to the potency calculation, a probability distribution of cancer potency estimates was derived using likelihood theory. The linear term (q1) of the multistage model fit to dose response data for a given site represents the cancer potency for that site. The cancer potencies for the affected sites were summed probabilistically, according to their distributions, to obtain a combined distribution. This combined distribution representing cancer potency for all selected sites affected by 3,3'-dimethylbenzidine dihydrochloride was derived through Monte Carlo analysis. The upper 95 percent confidence bound indicated by the combined distribution for these treatment-related tumor sites was taken as the cancer potency for 3,3'-dimethylbenzidine dihydrochloride.
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No Significant Risk Levels (nsrls) for the Proposition 65 Carcinogens 3,3'-dimethoxybenzidine and 3,3'-dimethoxybenzidine Dihydrochloride
The cancer potencies of 3,3'-dimethoxybenzidine dihydrochloride (commonly called odianisidine) and 3,3'-dimethoxybenzidine dihydrochloride were estimated from dose-response data for multiple treatment-responding tumor sites among male rats exposed orally to 3,3'dimethoxybenzidine dihydrochloride via drinking water (NTP, 1990). These sites were skin, Zymbal’s gland, preputial gland, small intest...
متن کامل[Studies on an efficient method for determining 3,3'-dimethylbenzidine in the workplace air].
BACKGROUND 3,3'-Dimethylbenzidene (DMB) is a substance classified into the group of carcinogens. The value of maximum admissible concentration for this substance in the workplace air is not specified in Poland. Bearing in mind that DMB is used in domestic companies there is a need to develop a sensitive method for determining 3,3'-dimethylbenzidine in the work environment. MATERIAL AND METHOD...
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EXPEDITED CANCER POTENCY VALUES AND NO SIGNIFICANT RISK LEVELS (NSRLs) FOR SIX PROPOSITION 65 CARCINOGENS: CARBAZOLE, MeIQ, MeIQx, METHYL CARBAMATE, 4-N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1 BUTANONE, TRIMETHYL PHOSPHATE
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EXPEDITED CANCER POTENCY VALUES AND NO SIGNIFICANT RISK LEVELS (NSRLs) FOR SIX PROPOSITION 65 CARCINOGENS: CARBAZOLE, MeIQ, MeIQx, METHYL CARBAMATE, 4-N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1- BUTANONE, TRIMETHYL PHOSPHATE
using an expedited methodology. The expedited approach represents the first level of a three-tiered risk assessment procedure currently in place for timely and efficient development of cancer potencies and Proposition 65 " no significant risk levels " (NSRLs) and has been shown previously to produce reliable potency values (OEHHA, 1992; Hoover et al., 1995). Values generated using the expedited...
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